赵良才《药理学》第3章：药效学.pptVIP

Relationship of ADR drug concentration side reaction Dose-response relationship Efficacy and potency * * * * * There are 2 fundamental types of endpoints that can be used to quantify the dose-effect relationship, graded and quantal. Graded - The graded dose-effect is measured on a continuous scale and the intensity of the effect is proportional to the dose, such as measuring the change in blood pressure after administering an antihypertensive agent. Grade dose-effect relationships can be measured in a single biologic unit that is exposed to a range of doses. Therefore, a graded dose-effect