药物基因组学的原理与应用.pptVIP

药物基因组学的原理与应用;（2）. 药物基因组学的发展;2．药物基因组学的概念、研究内容以及研究任务;（2）研究内容;（3）任务;3. 药物基因组学的研究步骤和方法;药物基因组学研究的主要方法和技术;药物基因组学研究的主要方法和技术;二. 药物基因组学的应用;续上页;2．促进新药的研究与开发;续上页;1. Defination;Loose Definitions;2. The difference and relation of pharmacogenetics and pharmacogenomics;Pharmacogenomics;3. The study areas of Pharmacogenomics;3.2. Drug targets;Polygenic and Drug Response;3.Pharmacogenomics of P-gp;Position and distribution of variated MDR1 gene (2);Pharmacogenomics of P-gp;The relationship of genotype and phenotype;Plasma levels of digoxin after rifampin induction of P-gp;;Time;SLCO1B1 and ABCB1 genotypes;Nishizato et al., Clin Pharmacol Ther 2003;三. 药物基因组学的研究现状和前景;The challenge of the future;思考题