含羧酸的吡咯缩氨基硫脲的合成、表征及溶解性终极_毕业论文.doc

含羧酸的吡咯缩氨基硫脲的合成、表征及溶解性  PAGE \* MERGEFORMAT 21 摘 要 现代生活中，癌症对人类生命和健康的威胁与日俱增，研发有效的抗癌药物一直备受各界关注。吡咯以各种形式的衍生物广泛地存在于自然界, 在生物体的发育、生长、能量储存和转换，生物体的各种信息传递等生命过程中起着重要的作用。氨基硫脲作为一种含硫酰肼，是合成抗结核药氨硫脲和磺胺药物的原料， 是一个重要的有机合成中间体。因此，本论文以2,4-二甲基-5-甲酰基-吡咯-3-甲酸和硫代氨基脲、4-甲基氨基硫脲、4-乙基氨基硫脲、4-异丙基氨基硫脲、4-苯基氨基硫脲为原料，合成了一系列含羧酸的吡咯缩氨基硫脲化合物。此外，我们对目标产物进行溶解性的测试，并通过红外光谱、核磁共振等光谱手段对产物进行了表征，希望能从中筛选治疗癌症的候选药物。 关键词：缩氨基硫脲、吡咯、羧基、溶解性 Abstract In our modern society, the threat of cancer disease to human life and health grows with time elapsing. More attentions have been paid to develop effective anti-cancer drugs. Various forms of pyrrole derivatives are widely existed in nature and play an important role in an organisms development, growth, energy storage and conversion and biometric information transmission of various life processes. Thiosemicarbazide, a sulfur-containing hydrazide, is the raw material of synthesized anti-TB thiourea and sulfa drugs and an important intermediate for organic synthesis. Therefore, in this paper, the series of pyrrole thiosemicarbazones compounds containing Carboxyl group were successfully synthesized by reacting 2,4-dimethyl-5-formyl-pyrrole-3 -carboxylic acid with thiosemicarbazide, 4-methyl thiosemicarbazide, 4-ethyl thiosemicarbazide, 4-iso propyl thiosemicarbazide, 4-phenyl thiosemicarbazide. Solubility of the target product was tested and then confirmed by IR and 1H NMR spectroscopy, we hope to search drug candidates for cancer treatment. Key word: thiosemicarbazone, pyrrole, carboxyl, solubility 目 录  TOC \o 1-3 \h \z \u  HYPERLINK \l _Toc389160450 摘 要  PAGEREF _Toc389160450 \h 1  HYPERLINK \l _Toc389160453 目 录  PAGEREF _Toc389160453 \h 3  HYPERLINK \l _Toc389160454 1引言  PAGEREF _Toc389160454 \h 4  HYPERLINK \l _Toc389160455 1.1席夫碱及其配合物的研究概括  PAGEREF _Toc389160455 \h 4  HYPERLINK \l _Toc389160456 1.1.1席夫碱的定义  PAGEREF _Toc389160456 \h 4  HYPERLINK \l _Toc389160457 1.1.2席夫碱的分类  PAGEREF _Toc389160457 \h 4  HYPERLINK \l _Toc389160458 1