灵芝预处理对脑缺血再灌注损伤海马神经元的保护.doc

SICENCE新闻发布 作者：张旺信 稿号：NRR_207_14 灵芝预处理对脑缺血再灌注损伤海马神经元的保护 药理研究发现，传统中药灵芝具有较强的抗氧化及抗炎作用。为此，来自中国山东省立医院杜怡峰教授所带领的团队设计了预先以灵芝水溶液灌胃治疗大鼠脑缺血再灌注损伤的实验方案，发现灵芝预处理可减少脑缺血再灌注损伤大鼠海马神经元缺失，降低海马和血清中丙二醛水平，提升超氧化物歧化酶水平，同时降低海马组织中炎症相关因子肿瘤坏死因子α和白细胞介素8的表达。表明灵芝通过抗氧化和抗炎作用可对脑缺血再灌注损伤大鼠海马神经元产生保护作用。相关文献发表于《中国神经再生研究（英文版）》杂志2014年8月第15期。 免疫组化染色显示，脑缺血再灌注损伤大鼠经3d灵芝水溶液灌胃后，海马组织中肿瘤坏死因子α的表达明显降低 Article: Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus, by Wangxin Zhang1, 2, Qiuling Zhang2, Wen Deng2, Yalu Li2, Guoqing Xing2, Xianjun Shi2, Yifeng Du1 (1 Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China; 2 Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China) Zhang WX, Zhang QL, Deng W, Li YL, Xing GQ, Shi XJ, Du YF. Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus. Neural Regen Res. 2014;9(15):1446-1452. 欲获更多资讯： HYPERLINK /Neural Regen Res Ganoderma lucidum pretreatment against cerebral I/R injury in the hippocampus Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects. Therefore, Prof. Yifeng Du and team from Shandong Provincial Hospital in China aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion (I/R) injury in rats. Their results showed that pretreatment with ganoderma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis factor-α and interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. These results which have been published in the Neural Regen