牙周病的发生.ppt

Immunity and Inflammation: Host Defense Against Microbial Plaque;;Histopathological fatures of gingival inflammation;;Page 和 Schrodeder 1976;Clinically healthy gingiva（The initial lesion）;Size (%volume) of various components of normal CT (NCT) and the infiltrated CT (ICT) at various days (4,14, and 28) after onset of plaque formation;;牙周病屬於感染性疾病導致宿主產生免疫反應;牙菌斑導致牙周病的機轉;牙周病致病菌之毒性因子 ;1. 菌體表面物質;1. 菌體表面物質;2. 相關的致病酶 ;2. 相關的致病酶 ;3. 毒素 ;;細菌侵入及破壞牙周組織的可能機轉 ;;;;;;;Chronic periodontitis;Aggressive periodontitis;;;Periodontal abscesses;免疫反應調控失常導致牙周病的機轉:分成二條主要系統;免疫反應調控失常導致牙周病的機轉:分成二條主要系統;先天性免疫反應與牙周病的關係 ;;;Events associated with acute inflammation;Vascular changes;Fluid exudate;Cellular exudate：白血球於血液中移動 ;;Cell migration;Phagocytosis;Chemical mediators of inflammation;Vasoactive amines and peptides;Plasma proteases (Fig 3-3);;;;Complement pathway;Regulators of complement activation;kallikrein-kinin system;Fibrinolytic clotting system;;Arachidonic acid metabolites (fig 3-4);;Platelet activating factor;Cytokines, chemokines, and growth factors;;In summary of PMNs in periodontal disease;;後天性免疫反應與牙周病的關係 ;牙周組織中免疫球蛋白;In summary of antibiotics in periodontal disease;In summary of antibiotics in periodontal disease;;B cell regulation processes;Complement;Complement promotes inflammation by generating the following;Systemic humoral immune response;;Homing –recruitment of specific inflammatory and immune cells to the periodontium;Homing of cells;細胞免疫中淋巴球與牙周病關係 ;T淋巴球在牙周病中的角色;Cytotoxic T cell:CD8 +;;;;Primary response immunoglobulin;Secondary response immunoglobulin;In summary of T and B cells;細胞免疫中的發炎調控物質與牙周病的關係 ;炎前胞激素;花生烯酸衍生物;花生烯酸衍生物;胞激素的功能分類;胞激素;;間質金屬蛋白酶