系统性红斑狼疮患者血清骨钙素的测定x.docxVIP

网址： HYPERLINK  第  PAGE 4 页，共  NUMPAGES 4 页 系统性红斑狼疮患者血清骨钙素的测定 系统性红斑狼疮患者血清骨钙素的测定 中华皮肤科杂志 1999年第6期第32卷 论著 作者：陈红清　陈志强　徐文严 单位：陈志强　徐文严（指导者）　中国医学科学院　中国协和医科大学皮肤病研究所；陈红清　现在广东医学院附属医院皮肤科，524001 关键词：红斑狼疮；系统性骨钙素肾上腺皮质激素 【摘要】目的　了解皮质类固醇对系统性红斑狼疮(SLE)患者的骨代谢及钙调节激素的影响。方法　放射免疫分析法测定了31例长期服用皮质类固醇的SLE患者血清骨钙素、甲状旁腺激素及降钙素水平。结果　采用皮质类固醇治疗的SLE患者血清骨钙素、降钙素水平明显下降，而血清甲状旁腺激???水平则明显升高，与对照组相比，在统计学上差异均具有显著性（P＜0.01），提示皮质类固醇可通过降低成骨细胞的活性而使骨形成受到抑制。结论　血清骨钙素可作为长期服用皮质类固醇的SLE患者进行骨代谢监测时的一项有效的生化指标。 Measurement of Serum Osteocalcin Level in Patients with Systemic Lupus Erythematosus(SLE): Implications for the Mechanism of Corticosteroid-induced Bone Loss CHEN Hongqing, CHEN Zhiqiang, XU Wenyan. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042 【Abstract】 Objective　To study the effect of long-term administration of corticosteroids on bone metabolism and calcium-regulating hormones in patients with systemic lupus erythematosus(SLE). Methods Serum concentrations of osteocalcin (BGP), parathyroid hormone (iPTH) and calcitonin (h-CT) were measured by radioimmunoassay in thirty-one SLE patients. Results Serum BGP and h-CT were reduced; but serum iPTH was increased; the differences were significant between SLE cases and healthy controls(P＜0.01). The results suggesed that corticosteroids inhibited bone formation by suppressing cell proliferation and protein synthesis in osteoblasts. Conclusion Serum BGP is an effective biochemical parameter in assessing bone turnover in SLE patients during long-term corticosteroids therapy. 【Key words】 Lupus erythematosus, systemic Osteocalcin Adrenal cortex hormones 系统性红斑狼疮（SLE）是以多系统损害伴多种自身抗体为特征的自身免疫性疾病，临床上一般应用皮质类固醇及免疫抑制剂进行治疗，特别是长期服用皮质类固醇，几乎不可避免地会出现或轻或重、甚至严重的不良反应。许多作者从组织形态学、骨活检、掌骨皮质厚度或骨密度测定等方面研究均发现接受皮质类固醇治疗的患者的骨量减少。为了了解皮质类固醇对SLE患者的骨代谢及钙调节激素的影响，我们测定了31例长期服用皮质类固醇的SLE患者的血清骨钙素（BGP)、甲状旁腺激素（iPTH）及降钙素（h-CT）水平，现将结果报道如下。 病例和方法 一、病例资料 女性SLE患者31例，为广州南方医院门诊就诊或住院病例，年龄16