复旦研究生《细胞免疫》asthma atherosclerosis.pdfVIP

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复旦研究生《细胞免疫》asthma atherosclerosis.pdf

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Journal of Molecular and Cellular Cardiology 72 (2014) 20–27 Contents lists available at ScienceDirect Journal of Molecular and Cellular Cardiology journal homepage: /locate/yjmcc Original article Allergic asthma accelerates atherosclerosis dependent on Th2 and Th17 in apolipoprotein E de?cient mice Lijun Wang a,c, Shanshan Gao a,WeiXua, Sijia Zhao a,JuanZhoua,c,NanpingWangd,ZuyiYuana,b,c,d,? a Department of Cardiovascular Medicine, First Af?liated Hospital of Medical School, Xian Jiaotong University, China b Key Laboratory of Environment and Genes Related to Diseases (Xian Jiaotong University), Ministry of Education, China c Key Laboratory of Molecular Cardiology, Shannxi Province, China d Cardiovascular Research Center, Xian Jiaotong University, Xian, Shaanxi 710061, China article info abstract Article history: Aims. The chronic in?ammation of atherosclerosis is regulated by Th1, while allergic asthma is controlled by Th2. Received 12 December 2013 The direct relationship between atherosclerosis and asthma is contradictory. The aim of this study was to inves- Received in revised form 27 January 2014 tigate the role of allergic asthma in atherosclerotic plaque formation and the change of CD4+ T cells subsets. Accepted 5 February 2014 ? ? Methods and results. Six-week C57BL/6J or apoE / mice were sensitized on day 0, 7 and 14, then exposed to Available online 14 February 2014 aerosolized 1% Ovalbumin (OVA) or PBS 30 min/day, 3 times/week for 8 or 16 weeks from day 14 onward. The results showed that allergic asthma mice models