母亲肥胖对后代的影响.pdfVIP

124 Tianjin Med J, January 2016, Vol. 44 No. 1 母亲肥胖对后代的影响 段洋 1，孙夫强 1，刘戈力 2△ 摘要：近年来母亲肥胖发病率明显增加，母亲肥胖可导致慢性炎症、氧化应激、细胞因子内稳态的改变，增加妊 DNA 娠不良结局的危险。怀孕前和怀孕过程中母亲肥胖的代谢状态能够改变胎盘 甲基化水平，且会引起胎儿“程 序化”改变，影响妊娠结局，增加后代发生肥胖相关的代谢综合征等慢性病风险。积极预防和干预母亲肥胖，可降低 不良妊娠结局，提高后代生存质量。 关键词:母亲；肥胖症；胎儿；代谢综合征；后代；影响；综述 722.19 A 10.11958/58828 中图分类号： 文献标志码： DOI： Effects of maternal obesity on the offspring DUAN Yang1, SUN Fuqiang1, LIU Geli2△ 1 Department of Neonatology, Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2 Department of Pediatrics, Tianjin Medical University General Hospital △Revisor E-mail：liugeli2001@126.com The prevalence of maternal obesity has risen dramatically in recent years. Maternal obesity increases the risk Abstract: of adverse pregnancy outcomes, and can lead to chronic inflammation, oxidative stress, the change of cell factor homeostasis. The metabolic status of maternal obesity in the pre-pregnancy and pregnancy can alter the level of DNA methylation in the placenta, change the fetal programming, influence the pregnancy outcomes, and increase the risk of obesity related metabolic syndrome and other chronic diseases of offspring. Actively preventing and intervening in the maternal obesity can reduce the adverse pregnancy outcomes and increase the survival quality of the offspring. mothers; obesity; fetus; metabolic syndromes; off