广西壮族腰椎间盘突出症血瘀证患者与TGF.docVIP

　　广西壮族腰椎间盘突出症血瘀证患者与TGF 广西壮族腰椎间盘突出症血瘀证患者与tgf-β1 -509c/t基因多态性及部分危险因素的关联研究 【关键词】 腰椎间盘突出症　中医证型　 危险因素　tgf-β1 -509c/t基因多态性 【摘要】 ［目的］探讨腰椎间盘突出症血瘀证患者及部分危险因素与tgf-β1 -509c/t基因多态性的关联性。［方法］筛选符合既定相关标准的广西壮族人群腰椎间盘突出症患者88例,分为血瘀证组30例与非血瘀证组58例，进行tgf-β1 -509c/t基因多态性检测，并观测患者的腰椎负荷强度等指标，观察部分危险因素以及部分危险因素和tgf-β1 -509c/t基因多态性的交互作用与腰椎间盘突出症中医证型的关联性。［结果］经非条件logistic回归foring groorphism and parts of the risk factors e of lumbar intervertebral disc protrusion in zhuang ethnic population from guangxi zhuang autonomic region 　　xu jian-ing, chen jing, et al 　　department of orthopedics, the first affiliated hospital to guangxi traditional chinese medicine university, nanning 530023, china 　　abstract: ［objective］to investigate the relationship bete and parts of the risk factors of lumbar intervertebral disk protrusion (lidp)and transforming groorphisms. ［methods］a total of 88 zhuang ethnic patients from guangxi zhuang autonomous region e and the other 58 orphism (snp) of tgf-β1 -509c/t and risk factors like lumbar burden intensity edicine syndrome of lidp e of blood stasis pattern of lidp in patients bar burden es （95%ci:1.334～1.872）of that in patients ild and middle lumbar burden (plt;0.05) , and the risk further increased 18.425 times（95%ci:1.767～ 3.693）after its accumulating orphisms in zhuang ethinic group in guangxi(plt;0.01).［conclusion］severe lumbar burden may be one of the risk factors of syndrome of blood stasis pattern of lidp in zhuang ethnic populational from guangxi. patients bar burden are susceptible to syndrome of blood stasis pattern of lidp. 　　key bar intervertebral disk protrusion; syndrome pattern of traditional chinese medinine; risk factors; transforming groorphisms 　　腰椎间盘突出症（lumbar intervertebral disk protrusion ,lidp) 是最常见的脊柱骨科疾病，中医辨证以血瘀证多见，国内外学者研究多年，但腰腿痛反复发作仍是目前很多医生和患者无法回避的问题。本文探讨tgf-β1 -509c/t(transforming groass index,bmi) 小于18.5 kg/m2或大于28.0 kg/m2；(4)吸烟指数大于300支/d·y者；(5)临床资料不完整。 　　1.5 临床指标观测方法 　　1.5.1 吸烟指数（smoking index,si）：按平均每天吸烟数目乘以吸烟年限评价，参考battie等方法［5］划分为不吸烟和吸烟两个等级