纳米混悬技术在中药制剂中的应用及发展趋势.PDFVIP

中草药= = =q==e=a= = 第 QT 卷= 第 S 期=OMNS 年 P 月 ·USR· ·专==论·= 纳米混悬技术在中药制剂中的应用及发展趋势 罗开沛，李小芳*，罗 佳，杨 露，刘海霞，林 浩，吴超群 成都中医药大学药学院 中药材标准化教育部重点实验室 四川省中药资源系统研究与开发利用重点实验室——省部共建国 家重点实验室培育基地，四川 成都 611137 摘 要：纳米混悬技术为改善难溶性中药有效成分和有效部位的溶解度和生物利用度提供了新的方法，在中药领域的应用与 发展中，是实现中药现代化、国际化的有效途径之一。主要对中药纳米混悬给药系统的制备方法、固化研究和应用进行综述， 并分析了目前所存在的问题，提出了解决问题的设想，以期促进纳米混悬技术在中药制剂中的开发与完善，扩大中药的应用 范围。 关键词：纳米混悬技术；中药制剂；生物利用度；溶解度；固化 中图分类号：R283.3 文献标志码：A 文章编号：0253 - 2670(2016)06 - 0865 - 07 alfW 10.7501/j.issn.0253-2670.2016.06.001 = = LUO Kai-pei, LI Xiao-fang, LUO Jia, YANG Lu, LIU Hai-xia, LIN Hao, WU Chao-qun The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine; Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province——Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China W Nanosuspension technology has provided a new method for improving the solubility and bioavailability of the effective components and the effective parts in Chinese materia medica (CMM). It is one of the effective ways to realize the modernization and internationalization in the application and development of CMM. This article mainly summarizes the preparation method, curing research, application of CMM nanosuspension drug delivery system, analyzes the existing problems, and puts forward some ideas, in order to promote the development and perfection of nanosuspension technology in CMM, and expand the scope of application of CMM. h W nanosuspension technology; Chinese