中性粒细胞性哮喘NADPH氧化酶-4过度表达与气道上皮.PDF

[ 文? 摘 ] 中性粒细胞性哮喘 NADPH 氧化酶 -4 过度表达与气道上皮 纤毛功能失调相关 Wing-Yan Heidi Wan, PhD, Fay Hollins, PhD, Louise Haste, PhD, Lucy Woodman, PhD, Robert A. Hirst, PhD, Sarah Bolton, PhD, Edith Gomez, PhD, Amanda Sutcliffe, PhD, Dhananjay Desai, PhD, Latifa Chachi, PhD, Vijay Mistry, BSc, Cédric Szyndralewiez, PhD, Andrew Wardlaw, PhD, Ruth Saunders, PhD, Christopher O’Callaghan, PhD, Peter W. Andrew, PhD and Christopher E. Brightling, PhD, FCCP From the Institute for Lung Health (Drs Wan, Hollins,Woodman, Bolton, Gomez, Sutcliffe, Desai, Chachi, Wardlaw, Saunders, and Brightling and Mr Mistry), Department of Infection, Immunity Inflammation, Glenfield Hospital, Department of Infection, Immunity and Inflammation (Drs Haste, O’Callaghan, and Andrew), Centre for PCD Diagnosis and Research (Dr Hirst), Department of Infection, Immunity and Inflammation, RK Clinical Sciences Building, University of Leicester, Leicester; and Genkyotex (Dr Szyndralewiez), Geneva, Switzerland. Drs Wan and Hollins were joint first authors on this manuscript. The following funding bodies were involved in this study: Wellcome Trust Senior Clinical Fellowship (C. E. B.), Airway Disease Predicting Outcomes through Patient Specific Computational Modelling (AirPROM) project (funded through FP7 EU grant), MAARA, NC3R, and the European Regional Development Fund (ERDF 05567) part funded the research laboratories. This article presents independent research funded by the Leicester Respiratory National Institute for Health Research Biomedical Research Unit. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. CORRESPONDENCE TO: Christopher E. Brightling, PhD, FCCP, University of Leicester, Glenfield General Hospital, Groby R