(1,3)Dglucan detection of invasive fungal infection in patients with hematologic malignancies.docVIP

 PAGE \* MERGEFORMAT 13 (1,3)Dglucan detection of invasive fungal infection in patients with hematologic malignancies [Abstract] Objective To evaluate the (1,3) D glucan ((1,3) D glucan, BG) testing as invasive fungal infections (IFI) rapid detection method for early diagnosis of IFI in patients with hematologic malignancies in significance. Methods temperaturegt; = 38 over 96 hours sustained, broad-spectrum antibiotic treatment, after reasonable invalid, or the initial treatment is effective but then again, the body temperature rise, 1 w antifungal treatment is not applied within the 39 patients with malignant tumors of blood for the study. 2 times a week in serum BG detection, continuous monitoring of 3 w. BG test with statistical method in the early diagnosis of sensitivity, specificity and positive predictive value (PV +), negative predictive value (PV). At the same time a continuous change in serum concentrations of fungal antigens was observed with disease progression and prognosis of relationships. Results 39 enrolled patients, 31 cases were diagnosed IFI, BG test positive rate was 93.5% (29/31) (cut point value 80 pg / ml), sensitivity was 93.5%, specificity 75%, PV +93.5%, PV 75.0%, Kappa = 0.685. the first positive results seen in the serum BG clinical diagnosis clinical diagnosis before 17 d ~ after 2 d, the average appeared before clinical diagnosis (2.7 + -3.3) d. course of antifungal treatment, the serum BG level of deterioration in patients with infections continues to rise, improvement in the treatment of patients decreased significantly. conclusions as IFI diagnosis, BG test results and clinical diagnosis of IFI in good agreement; with traditional culture method compared with the early, rapid, and the advantages of high sensitivity and specificity. [Keywords:] of invasive fungal infection;; (1,3) D glucan; specificity; sensitivity Along with receiving high-dose chemotherapy, stem cell transplantation in the treatment of hematologic