37 cases of children with Kawasaki disease analysis of T cell subsets.docVIP

 PAGE \* MERGEFORMAT 6 37 cases of children with Kawasaki disease analysis of T cell subsets Of: Yang Ying, Tan Pei Jun, Ni Xinli Huang Yun, Song Shan Road [Abstract] Objective of 37 children with Kawasaki disease (KD) T-cell subsets were analyzed and summarized, to improve the situation of the understanding of the immune disease. Methods retrospectively analyzed 37 cases of T-cell function in Kawasaki disease. The results Kawasaki T lymphocytes in acute regulatory network of existing imbalances. CD4 cell count increased, CD8 cell count, CD4/CD8 ratio significantly increased, suggesting that the immune system is activated. Conclusion abnormal activation of T cells is activation of the immune system in children with KD lead to vascular initiating inflammatory injury links and key steps to actively detect children with acute KD T cell subsets changes, the understanding of the situation with a certain KD value of immunization in children. [Keywords:] Kawasaki disease; children; T cell subsets Kawasaki disease (KD) is a systemic vasculitis as the main lesion of acute febrile rash illness, the clinical features of fever, bilateral non-exudative conjunctivitis, red lips and oral mucosa, changes in extremities, rash and cervical lymphadenopathy. without treatment about 15% to 25% coronary artery or coronary artery aneurysms, and even can cause ischemic heart disease or sudden death [1], has become the main reason for acquired heart disease of children, but The etiology, pathogenesis is not clear. From the Epidemiology and pathogens or toxins speculated superantigen induced immunological abnormalities [2], that have a strong superantigen activation of T cell function, through the T cell-mediated vascular inflammatory response [3]. our hospital 37 cases were determined in peripheral blood of acute KD children with CD4, CD8, CD4/CD8, CD3 cell levels in order to observe the acute phase of KD in children with T cell function. 1 Materials and Methods 1.1 G