Abnormal activation of tyrosine kinases in the pathogenesis of hematologic malignancies.docVIP

 PAGE \* MERGEFORMAT 31 Abnormal activation of tyrosine kinases in the pathogenesis of hematologic malignancies Abstract protein tyrosine kinase (protein tyrosine kinase, PTK) in regulating cell growth, activation and differentiation of the signal transduction plays an important role. Gene mutation (mostly from chromosomal translocation) or overexpression of kinase can abnormal increase of PTK activity, and mediated by abnormal signal transduction, the occurrence and development in a variety of hematological malignancies plays a major role. In chronic myeloproliferative disorders (CMPD), acute myeloid leukemia (AML) and anaplastic large cell lymphoma in the pathogenesis of both the existence of the abnormal activation of PTK. PTK-related further study the pathogenesis of hematological malignancies, can speed up the specific molecular target therapy are reviewed. Keywords: tyrosine kinase hematologic malignancies; gene mutation Abnormal Activation of Tyrosine Kinases and Its Role in the Pathogenesis of Hematological Malignancies - Review Abstract Protein tyrosine kinases are key participants in signal transduction pathways that regulate cellular growth, activation and differentiation. Aberrant PTK activity resulting from gene mutation (often accompanying chromosome translocation) or overexpression of these enzymes plays an etiologic role in several clonal hematopoietic malignancies. Other than the causative effect of PTK product of the bcr / abl fusion gene on chronic myelogenous leukemia (CML), more evidence suggests that mutated tyrosine kinases are pivotal in the pathogenesis of most of other chronic myeloproliferative disorders, such as chronic myelomonocytic leukemia (CMML) and hypereosinophilic syndrome (HES). And the exciting results in several dependent groups in 2005 showed that a single nucleotide JAK2 somatic mutation (JAK2V617F mutation) was found to be involved in the pathogenesis of polycythemia vera (PV), essential thro