About Medicinal Chemistry R amp; D system construction aid.docVIP

 PAGE \* MERGEFORMAT 11 About Medicinal Chemistry R amp; D system construction aid Of: Lei Lei, Zhang Huimin, Cui Meng, Yin Aining, TRADITIONAL [Keywords: supporting R amp; D system in medicinal chemistry, drug development, traditional Chinese medicine database Modern research shows that, from medicine to find new active ingredients or lead compounds to develop new drugs effective way. Chinese medicinal plants are after thousands of years of clinical use, through natural selection, and its efficacy has been fully proved From the hundreds of thousands of Chinese medicinal plants starting to discover new drugs, the hit rate is much higher, the risk is much smaller, I hope to be much larger [1]. For example, vinca alkaloids derived Navelbene, Topotecan and camptothecin derivatives Irinitecan, Docetaxel and paclitaxel are derived from a significant antitumor effect. how to build a new drug for medicinal chemistry research and development assistance in the development of new drug R amp; D system to be of concern. So far, there have been many domestic and foreign chemical-related databases and traditional Chinese medicine [2-4]. Within the system in the Chinese Academy of Sciences, Kunming Institute of Botany, Shanghai Institute of Organic Chemistry, Wuhan Botanical Garden, Ecological Geography of Xinjiang, the process works, and other units are with different characteristics to establish their own database of medicinal plants. The advantage of the database as the information involved in medicine records are complete, and traditional Chinese medicine chemical composition of the chemical properties, physical properties and pharmacological nature of the content of useful information displayed in close contact very comprehensive. but most of the database search function stop at the level of association. we have built chemical supporting R amp; D system of Chinese medicine is not only associated with search features, more importantly, it is the modernization