About Reduqing rabbits with endotoxin fever oral body temperature and plasma nitric oxide.docVIP

 PAGE \* MERGEFORMAT 11 About Reduqing rabbits with endotoxin fever oral body temperature and plasma nitric oxide Of: Zhou Dayong, Zhang Zongming, Hanning Lin, Li Xueling, Chen Shuangping, Fan Quan, Wang Kai, on behalf of the king [Abstract] Objective To observe Reduqing oral solution (Du Qing) in rabbits with endotoxin fever the body temperature and plasma nitric oxide (NO) levels, and compare the efficacy of different doses. Methods endotoxin injection method for producing heat rabbits, 60 rabbits were randomly divided into 6 groups: compound acetyl salicylic acid group, GAO toxic heat dose group, middle dose group Reduqing, Reduqing low dose oral Shuanghuanglian group, model group, n = 10, observed temperature changes between each group and plasma NO levels. Results Compared with model group, Reduqing in the dose group and high dose group the body temperature of febrile rabbits significantly reduced role, and antipyretic compound acetylsalicylic acid group than the action time Reduqing low dose group and shuanghuanglian rabbit fever group had no significant effect of temperature, heat toxin GAO dose 4 h after treatment, the plasma NO level was significantly lower than group. Conclusion lofty toxic heat in the dose and dose Reduqing to reduce endotoxin-induced fever in rabbits body temperature, decreased plasma NO levels. [Keywords:] Reduqing oral, endotoxin-induced fever; nitric oxide, rabbit Exogenous high fever is a common clinical emergency. Emergency department of our hospital since 1987 with fleas off decoction treatment, to achieve better efficacy [1], and in 1997 the hospital made its improved formulations - oral Reduqing (hereinafter referred to as “Reduqing” .) To further study its mechanism of action, the author observed that the drug rabbits with endotoxin fever the body temperature, plasma nitric oxide (NO) and other effects, are reported below. 1 Materials 1.1 Animals 60 Chinchilla rabbits, weighing 1.8 ~ 2.3 kg, either se