About APS on myocardial ischemia - reperfusion injury protective effect.docVIP

 PAGE \* MERGEFORMAT 10 About APS on myocardial ischemia - reperfusion injury protective effect Of: Zhang Zhuo, Chen Lixin, Songchong Shun, Qin bloom, Ren Ying, Guo Jing, Liang Jia Kou [Abstract] Objective To investigate the APS on reperfusion induced cardiac hemodynamic, mechanism and its relationship with oxygen free radicals. Methods of isolated working heart model of ischemia - reperfusion, and set the program control group, ischemia - reperfusion injury group, APS (50 mg / mL perfusate) in the treatment group. Results Ischemia - reperfusion group, aortic pressure (AP), left ventricular systolic pressure (LVSP), maximum change of left ventricular pressure Rate (+ -dp/dtmax) decreased significantly (P lt;0.05), while left ventricular end diastolic pressure (LVEDP), isovolumic diastolic ventricular pressure decline time constant (T value) was significantly higher (P lt;0.05), heart output (CO), stroke volume (SV), cardiac index (CI), stroke index (SI) decreased significantly (P lt;0.05, or P lt;0.01), coronary flow (CF) decreased significantly (P lt; 0.05), the APS group systolic and diastolic function were good recovery, a significant role in expanding the highest (P lt;0.05). ischemia - reperfusion myocardial superoxide dismutase (SOD) were significantly decreased, LPO levels increased myocardial oxygen free radical spectrum signal (OFR) increased SOD content of APS increased the treatment group, LPO content, OFR spectrum signal decreased, and ischemia - reperfusion group were P lt;0.05. Conclusion APS oxygen free radicals The effect may be the improvement of cardiac hemodynamics, myocardial ischemia - an important mechanism of reperfusion injury. [Keywords:] APS, myocardial ischemia - reperfusion injury Abstract: Objective To research the cardioprotective effect of Astragalus Membranaceus Polysaccharide (AMP) on hemodynamic and oxygen free radicals in myocardial ischemia followed by reperfusion. Methods By using experimental rats cardiac model,