About Sal Sal A and B compared to improve myocardial ischemia.docVIP

 PAGE \* MERGEFORMAT 8 About Sal Sal A and B compared to improve myocardial ischemia Study: Song Yanping, Ling Shan, Wu Jing, Miao love Rong, Zhao Gang [Abstract] Objective To observe the Chadan acid A and Sal B on myocardial ischemia. Methods coronary artery ligation and intravenous pituitrin two methods to observe sublingual injection of Sal A 10,5,2.5 mg / kg and Sal B 10 mg / kg in rats at different time points of ECG and serum creatine kinase (CK), lactate dehydrogenase (LDH) and the size of myocardial infarction. Results Dan phenol acid A 10,5,2.5 mg / kg and Sal B 10 mg / kg of coronary artery ligation model of acute myocardial infarction due to a lower degree of ECG ST segment elevation, reduce infarct size and lower serum CPK, LDH’s role, which Sal A 10,5 mg / kg was significantly higher than the potency of Sal B, 2.5 mg / kg the role of Sal A is equivalent to 10 mg / kg Sal B; after intravenous injection of pituitary vasopressin induced acute myocardial infarction with ST-segment elevation reduced the role of the degree, of which Sal A 10,5 mg / kg significantly stronger than the role of Sal B, 2.5 mg / kg the role of Sal A and 10 mg / kg Sal B was no significant difference. Conclusion 10,5 mg / kg Sal A myocardial ischemia improved significantly stronger than 10 mg / kg Sal B, 2.5 mg / kg Sal A role in improving myocardial ischemia is equivalent to 10 mg / kg Sal B. [Keywords:] Sal A; Sal B, rats, myocardial ischemia Abstract: Objective To investigate the effects of salvianolic Acid A and B (Sal A, Sal B) on acute myocardial ischemia of rats. Method The rat model with acute myocardial ischemia was established by coronary ligation and intravenous injection of posterior pituitary. The effect of Sal A 10, 5, 2.5 mg / kg and Sal B 10 mg / kg on the electrocardiogram of different time points, serum creatine kinase (CK), lactate dehydrogenase (LDH) and myocardial infarction area were observed. Results To the rat model was established by coronar