Acanthopanax senticosus injection of vascular dementia in rats.docVIP

Acanthopanax senticosus injection of vascular dementia in rats.doc

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 PAGE \* MERGEFORMAT 8 Acanthopanax senticosus injection of vascular dementia in rats Of: Xiexiang Lin Zou Hongbin Li Ye Liu Kai Zhao Li Wei Ke Liu Hongyan [Abstract] Objective senticosus injection on vascular dementia (VD have therapeutic effects in rats. Methods bilateral common carotid artery ligation and 16 w, VD rat model, the Morris water maze test, and the cortex and the step down test hippocampal pathology, Acanthopanax injection of VD. Results Compared with model group, Acanthopanax injection water maze rats at day 3 to 6, the latency was significantly shorter (P lt;0.05 or P lt;0.01, 3 days to reach the platform run-length was significantly shorter (P lt;0.05, day 7 in rats in the 2 min significantly increased the number of cross-platform (P lt;0.05, the strategy of finding the platform from the edge of the type, random type into trend-based, linear type significantly increased (P lt;0.05 or P lt;0.01, day 1, day 2 platform significantly fewer errors (P lt;0.05, significantly reduced injection VD Acanthopanax cortex and hippocampus of the pathological changes. Conclusions thorn five-filling injection on VD rats have therapeutic effects. [Keywords:] Acanthopanax injection, vascular dementia, learning and memory, rat Acanthopanax senticosus stems and leaves from the injection is made, the main component of ASS (Acanthopanax senticoside saponins, ASS, clinical and blood circulation drugs, cholinesterase inhibitors, combination, widely used in the treatment of cerebral vascular disease, particularly in the treatment of ischemic cerebrovascular disease has made a good effect. ASS on vascular dementia (VD clinical efficacy is the urgent problem. This study was to investigate the Ciwujia injection Is there treatment of VD rats, provide a scientific basis for clinical application. 1 Materials and methods 1.1 Animals Male Wistar rats were 36, weight 350 ~ 400 g, by the Changchun High-tech Medical Experimental Animal Center, Certificate of

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