Activated protein C resistance and pregnancy-induced hypertension.docVIP

 PAGE \* MERGEFORMAT 11 Activated protein C resistance and pregnancy-induced hypertension Keywords:: activated protein C resistance to factor V Leiden mutation in pregnancy-induced hypertension syndrome Summary Pregnancy induced hypertension syndrome (PIH) is a pregnancy-specific dangers of serious complications. It has undergone extensive research and continuously made new progress, however, at present its exact cause is still unclear. In this paper, activated protein C resistance in pregnancy-induced hypertension are reviewed. The biochemical characteristics of protein C Protein C (protein C) is a glycoprotein synthesized in the liver, the molecular weight of 62000dal. It is a vitamin K-dependent proenzyme (zymogen), in thrombin - thrombomodulin complex (thrombin - thrombomodulin complex) is activated under the action. Activated protein C (activated protein C, APC) is a coagulation factor Va and VIIIa of the physiological inhibitory factor, protein S (protein s) exists, APC selectively crack coagulation factors Va and VIIIa, thereby playing a role in anti-coagulation . APC can be inactivated through the role of plasminogen activator inhibitor of fibrinolysis. Through this mechanism, plasminogen activator be protected without being inhibited, so that plasminogen into plasmin, followed by digestion of the fibrin clot. Anticoagulant protein C system, characteristics of the strict constraints of thrombosis [1,2]. APC resistance in the mechanism APC resistance (activated protein C resistance) in the last five years to discover new things. 1993 Dahlhack such as APC resistance described for the first time. That the family of the incidence of thromboembolic disease mechanism is based on the APC is characterized by poor anticoagulant response. In healthy human blood by adding exogenous APC, the partial thromboplastin time (partial thromboplastin time, PTT) on the extension, because coagulation factors Va and VIIIa by APC are inactivated; some patients because of