Acute stress in rats with chronic heart failure and evaluation of model.docVIP

 PAGE \* MERGEFORMAT 11 Acute stress in rats with chronic heart failure and evaluation of model Of: Zhang Xiaoxia, Wu Xuesi, Han Zhihong, m SOAR [Abstract] Objective To establish a state of chronic heart failure rat model of acute stress and evaluated. Methods Wistar rats with repeated intraperitoneal injection of doxorubicin chronic heart failure, 6 weeks, hemodynamic and pathological evaluation of the line. Chronic heart failure rats were given intraperitoneal injection of LPS lead to acute stress, Blood pressure, heart rate and heme oxygenase 1 (HO 1) expression. Results intraperitoneal injection of doxorubicin were prepared successfully with chronic heart failure rats. with normal group, model group, myocardial fibrosis and cardiac myocyte hypertrophy, left ventricular contraction and relaxation of the maximum rate (+ -LVdp/dtmax) decreased significantly. peritoneal injection of lipopolysaccharide success should lead to acute heart failure in rats shock, 0.5h after injection the heart rate and blood pressure began to rise, 1h and reached the peak after the injection 6h HO 1 expression was increased, 12h increased even more significant, than rats with heart failure increased more significantly in normal rats. Conclusion bacterial lipid polysaccharide intraperitoneal injection of doxorubicin led to heart failure can be successfully produced acute stress in rats, acute exacerbation of chronic heart failure study the pathological state of a reliable animal model. [Keywords:] Chronic heart failure, stress, heme oxygenase, rat ABSTRACT: Objective To establish the rat model of acute stress during chronic heart failure and evaluate it. Methods Male Wistar rats were injected adrimycin (ADR) via abdominal cavity to induce heart failure. Cardiovascular dynamics and heart pathology were measured. Rats with heart failure received bacterial lipopolysaccharide (LPS) 0.2mg/kg by peritoneal injection to induce acute stress, and we measured blood pressure, heart