Adenocarcinoma of matrix metalloproteinase inhibitors1,22,9 and the expression.docVIP

 PAGE \* MERGEFORMAT 20 Adenocarcinoma of matrix metalloproteinase inhibitors1,22,9 and the expression Of: Chen Qian, Ke Juan, Wang Ji whole, Deng Huaici [Abstract] Objective To investigate the colorectal cancer tissue matrix metalloproteinase 2, 9 (MMP 2, 9) and their inhibitors 1, 2 (TIMP 1, 2) and its clinical significance. Methods Immunohistochemistry SP method Detection of MMP 2, MMP 9 and TIMP 1, TIMP 2 in 30 cases of colorectal adenocarcinomas and corresponding normal tissue in the cutting edge of expression. The results of colorectal adenocarcinoma MMP 2, MMP 9 and TIMP 1 expression was significantly higher than that of the positive normal peripheral tissues (P lt;0.05), and the degree of tumor differentiation, depth of invasion, Dukes stage and lymph node metastasis was positively correlated (P lt;0.05); TIMP 2 in colorectal adenocarcinoma with low expression (P lt;0.05), and with depth of invasion, Dukes stage and lymph node metastasis was a negative correlation (P lt;0.05), and tumor differentiation was no significant correlation (Pgt; 0.05); MMP 9 and TIMP 1 expression was significantly related (r = 0.4924, P lt;0.05) . Conclusion MMP 2, MMP 9 and TIMP 1 expression and colorectal cancer over the invasion, metastasis of, useful for assessing the combined detection of the malignant biological behavior of colorectal cancer and prognosis. [Keywords:] Colorectal cancer; matrix metalloproteinase; tissue inhibitor of metalloproteinase; immunohistochemistry ABSTRACT: Objective To study the expressions of matrix metalloproteinase 2 (MMP 2), matrix metalloproteinase 9 (MMP 9) and their inhibitors, tissue inhibitor of metalloproteinase TIMP 1 and TIMP 2, in human colorectal cancer and their clinical significance. Methods The expressions of MMP 2, MMP 9, TIMP1 and TIMP 2 in 30 primary colorectal tumors and adjacent noncancerous tissues were detected by immunohistochemical SP method. Results The positive rates of MMP 2, MMP 9 and TIMP 1 in colorectal