Adriamycin human serum albumin microspheres and Process Optimization.docVIP

 PAGE \* MERGEFORMAT 8 Adriamycin human serum albumin microspheres and Process Optimization Authors: ZHANG Yan-qiu, Xu lot, Pan, Goyang, GAO Qi-pin [Abstract] Objective: Preparation of a new technique of adriamycin human serum albumin microspheres (ADR  HAS  MS), and to optimize their best preparation process. Methods: Adriamycin (ADR), human serum albumin (HAS) as material, uses ultrasonic atomization  chemical cross-linking technology to prepare ADR  HAS  MS; and apply the orthogonal design method to determine their preparation process. RESULTS: The microspheres showed spherical optical microscope observation, round the whole particle size distribution range of 2 ~ 5 μ m, average particle size of 2.165 μ m, drug loading, encapsulation efficiency, respectively (3.174 ± 0.137), (75.11 ± 3.127). Conclusion: This technique can be realized continuously, batch production, both industrial production to meet demand, but also between the quantities to ensure product stability, has a good prospect. [Keywords:] adriamycin human serum albumin microspheres Preparation of orthogonal design Albumin microspheres (albumin microsphere) is a human or animal albumin made of spherical micron particle size of complexes [1]. The early study of albumin microspheres concentrated in the radiation field of medicine, used to check abnormal pulmonary circulation [2]. Later it was discovered that albumin microspheres is not only biodegradable, non-toxicity and antigenicity, but also for hydrophilic drugs have a higher load capacity, it is suitable for use as drug carrier and, therefore, applied to pharmaceutical preparations, especially anti-cancer drug formulations study [3  4]. In this study, the use of ‘albumin microspheres preparation instrument’, using ultrasonic atomization  chemical cross-linking agent prepared by liver targeting agents ADR  HAS  MS, can be achieved by controlling the size targeting. To particle size and its distribution, drug loading, encap