Add traditional Chinese medicines chemical detection method of phenobarbital.docVIP

 PAGE \* MERGEFORMAT 8 Add traditional Chinese medicines chemical detection method of phenobarbital Author: Xue Heng Yue, Wang Yulan, at dawn, Rong Hu, Wen-Zhen Wang [Keywords:] traditional Chinese medicine Abstract: Objective To investigate the anti-epileptic class of chemicals added to traditional Chinese medicines phenobarbital detection methods. Methods of Chemistry Identification of functional group specificity and high performance liquid chromatography method initially confirmed using high performance liquid chromatography - mass spectrometry in order to reference substance than the right for final approval. Results and Conclusion The method is simple, rapid, accurate and reliable. Keywords: phenobarbital; traditional Chinese medicine preparation; thin-layer chromatography; high-performance liquid chromatography; high-performance liquid chromatography-mass spectrometry Determination Methods of Phenobarbital in Traditional Chinese Medicinal Preparation Abstract: ObjectiveTo identify a method for the test of phenobarbital mixed in traditional Chinese medicine (TCM) preparations.MethodsChemical method and HPLC method were established for the determination of the organic extract of TCM preparations, and phenobarbital was last identified by comparation of samples with standards in HPLC-MS.Results and ConclusionThe samples were determined and contained phenobarbital.The method is simple, accurate and reliable. Keywords:: Phenobarbital; Traditional Chinese medicine (TCM) preparations; TLC; HPLC; HPLCMS Anti-epileptic drugs present many different types. One category is the phenobarbital phenobarbital acid derivatives, a major role in the central nervous system at different levels, with the non-specificity of inhibition. Some home-made traditional Chinese medicines illegally added to increase the efficacy of phenobarbital class of drugs, because there is no control of their dosage, clinical application is easy to produce liver and kidney toxicity, cause ha