Advances in Research on heat.docVIP

 PAGE \* MERGEFORMAT 10 Advances in Research on heat Keywords:: fever Progress Fever is the body of a complex physiological response characterized by increased cytokine release, resulting in heat-reactive protein. Fever is the body’s research progress to elaborate. First, pyrogenic cytokines currently considered, interleukin -1 (IL-1), tumor necrosis factor-α (TNF-α ), IL-6, interferon (INF) is a pyrogenic cytokines. These four kinds of cytokines and their receptors are interrelated, affect each other. Their molecules were 17000 ~ 3000, normal is difficult to detect. The source of its secretion and wide, and the plasma half-life is very short, target a variety of organizations, including the body organization. After the release of cytokines can be detected in body fluids and play a systemic, localized biological effects. Heat-induced central role of cytokines may include direct and indirect role in mediating the central point in turn influence the release of cytokines induced by heat. When exogenous pathogens (endotoxin or virus) violation of the body, may cause a particular mode of heat-induced cytokine release, cytokine-induced fever between the regulator and finally identify the target cell receptors, especially the anterior hypothalamic preoptic area leaf nerve cells, receptor-mediated activation of phospholipase A, and to arachidonic acid as substrate activation of cyclooxygenase pathway. Some cytokines can directly make cyclooxygenase expression and arachidonic acid metabolism to increase, resulting in prostaglandin (PGE). PGE is very easy to diffuse through the blood-brain barrier, thus affecting the central nervous system thermoregulatory yuan. The study also found that peripheral nerves can signal transduction to the external heat thermoregulation center. On the contrary, the body there is a feedback regulatory mechanism to control the temperature increases. When the PGE fever caused by acting on the hub, but also act on peripheral and downward ad