Adverse effects of interferon.docVIP

 PAGE \* MERGEFORMAT 16 Adverse effects of interferon Abstract This paper reports the application of the interferon-emergence of some adverse reactions, to remind clinicians to pay attention when in use to ensure the safety of drug use. Keywords: interferon; adverse reaction; Anti-Virus Interferon with anti-virus, anti-tumor, inhibit cell proliferation and enhance cellular immune function role as a viral and tumor effective drugs organisms has been widely used in treatment of viral diseases. However, some patients with the application process, in addition to common adverse reactions: fever chills, muscle pain, headache, fatigue, anorexia, nausea, may also be some rare, severe adverse reactions, clinical and should be sufficient attention. A hyperglycemia [1] Patients, male, due to chronic hepatitis B admitted to hospital. Past without diabetes, kidney disease, heart disease, thyroid disease, psychiatric history and history of drug and food allergies, their father had a history of diabetes. Admission, fasting plasma glucose 4.6mmol / L, postprandial blood glucose 7.2mmol / L, B Chao: diffuse hepatic injury. To be IFN-α (Lee points to) 3 million u im a day one time, a month later changed to every other day a time, treatment to the first 6 months when the end of thirst, weight loss, check fasting blood glucose: 16.8mmol / L, normal liver function. Disable interferon to regular insulin 10u, 6u and 8u three meals a day before the subcutaneous injection. After 1 week fasting blood glucose: 6.7mmol / L, postprandial blood glucose: 7.8mmol / L, but the insulin can not reduction, or blood sugar abnormalities. History of patients with no other medication, it may be the result of interferon caused by hyperglycemia. 2 acute aplastic anemia [2] Patients, male, 61 years old, fatigue, chest tightness, a more than a year, adding seven days hospitalization and a weak chest years ago lived in a hospital, it was