Adsorption resin to reduce acid in animal experimental study.docVIP

 PAGE \* MERGEFORMAT 35 Adsorption resin to reduce acid in animal experimental study Keywords: Resin Adsorption acid animal experiments ANIMAL EXPERIMENTAL STUDY ON EFFECT OF RESIN ADSORPTION ON DECREASE OF CHOLIC ACID Keywords:: Resin adsorption; Cholic acid; Animal experiment Hyperbileacidemia appeared in a variety of liver disease. In almost all hepatobiliary diseases, acute lesions in bile acid abnormal rate of up to 100%, chronic degenerative diseases of the liver and gallbladder abnormalities of serum bile acids up to 92%. When the bile acid excretion rapidly increased by more than kidney function, the patient appeared in a high-acid hyperlipidemia, and its accompanying symptoms of itching. Bile acid content is too high, the body of great danger, not only will cause the body a series of poisoning symptoms, and because bile acids in the blood, including a variety of generation of radio, including the accumulation of toxic substances will further exacerbate liver damage. This routine is almost ineffective [1], in order to improve the patient’s quality of life for liver transplant may be imposed to prepare for the spontaneous recovery of liver failure, and improve liver function, reduce liver damage and to facilitate their regeneration, hemoperfusion adsorption to remove these fat-soluble substance in the molecule is an effective treatment [2,3]. Blood purification for the domestic high-bile acids in the blood clearance gap, combined with domestic and foreign research data, the experimental use of new highly efficient NK-111 series of resins, animal models of jaundice in the blood acid adsorption to explore the adsorption of bile salt and blood-phase capacitive for the clinical treatment of high blood perfusion of bile acidemia provides the most direct basis. 1 Materials and methods 1.1 Materials A physical dog: weight 14 ~ 16kg, male and female open. 2 NK-111 Series Resin: Nankai Instit