Adverse effects of metronidazole.docVIP

 PAGE \* MERGEFORMAT 5 Adverse effects of metronidazole Alias metronidazole metronidazole, metronidazole is derivative, it has anti-trichomoniasis, amoebiasis and broad-spectrum anti-anti-anaerobes, this drug is WHO in 1978 as the basic anti-infective drugs . With a wide range of clinical applications, adverse reactions gradually increased. This article has been published on the domestic literature and I met at work cases, are summarized below. 1 severe vomiting According to Zhu reported [1], 1 male patients abscess in his left leg abscess incision and drainage lines Seoul, intravenous infusion of 0.2% metronidazole 200ml, when the patient drops to 160ml water samples will be 200ml, vomiting more than 10 times, the symptomatic treatment , 3 days after the vomiting and diarrhea only. 2, kidney damage A male patient hospital urethral itching, urine routine examination several times normal, to metronidazole, norfloxacin the 0.2g, half an hour after conscientious numb tongue and lips, hands, genital itching and a burning dry, followed by systemic skin redness, associated with herpes region of both kidneys appeared the next day pain, gross hematuria. deactivated metronidazole, only after taking norfloxacin, no further adverse reaction. 3 hemolytic anemia A female hospital patients with acute appendicitis intravenous metronidazole, 2 days, dizziness, backache, chills, general malaise, accompanied by ringing in the ears, and jaundice, soy sauce-like urine, feces hemoglobin test ++++, no red blood examination, urine bilirubin negative, urobilinogen positive, discontinued and symptomatic treatment, 3 days after the lighter color of urine after 1 week recovery. 4 severe hypokalemia According to Han Lingdeng reported [2], for obstetric and gynecological surgery intravenous metronidazole to reduce or avoid gynecologic surgery infections, in the 1011 cases occurred in 4 cases of low potassium levels, the occurrence rate of 0.19%