Adverse reactions of quinolones.docVIP

 PAGE \* MERGEFORMAT 5 Adverse reactions of quinolones [Keywords:] quinolones Since the first generation of quinolones nalidixic acid inception, has been 40 years of history. Are generally widely used in the clinical third and fourth generation products. The common denominator with 4 - the basic quinolone nucleus, for synthetic, selectively inhibit bacterial DNA gyrase impede DNA replication, leading to bacterial DNA synthesis and repair can not be caused by normal sterilization. The advantage of a broad spectrum antimicrobial, antibacterial effect strong absorption of oral injection well, a high blood concentration, tissue distribution quickly and less drug resistance. Clinical use in recent years, the amount of every year. However, with the increase in applications and research in-depth, adverse reactions (ADR) reports an upward trend, especially the third generation of the most common. In this paper, the actual clinical cases in our hospital and literature information on the ADR to make a summary quinolones to attract our attention. An adverse reaction (ADR) 1.1 Digestive system reactions mainly gastrointestinal disorders, with an average incidence rate of 10% to 13.4%, symptoms include nausea, vomiting, abdominal pain, abdominal discomfort, indigestion, flatulence, salivation, constipation and so on. Oral majority, the general self-healing after drug withdrawal. 1.2 central nervous system (CNS) response to an average rate of 2.1% to 3%, mainly manifested as dizziness, insomnia, anxiety, dizziness, tinnitus, visual abnormalities, fatigue, nightmares and so on. Severe can cause paranoia, coma, convulsions and seizures. The principle is a certain amount of fat-soluble drug molecules can enter the brain through the blood-brain barrier, so that increased excitability of the central nervous system. 1.3 Common for allergic rash, acute urticaria, drug fever, fixed drug eruption. Severe exfoliative dermatitis, acral bullous epidermal necrosis lax drug eruption