Aloe-emodin glycoside-DNA Interaction.docVIP

 PAGE \* MERGEFORMAT 13 Aloe-emodin glycoside-DNA Interaction Authors: Xin Wei Yu, Wen-Jie Mei, Liu Jun [Abstract] Objective To investigate the aloe-emodin glycosides and DNA interactions. Methods The electronic absorption spectra, fluorescence emission spectra, viscosity, gel electrophoresis experiments and experimental research. The results and conclusions of aloe-emodin way to insert DNA molecules; high concentration of aloe-emodin glycosides can make Bel  7402 hepatoma cells by a super-helical configuration of DNA into a notch configuration. [Keywords:] aloe-emodin glycosides; molecular recognition; gel electrophoresis; DNA Abstract: The binding properties of barbaloin to DNA were investigated by UV  visible electron absorption spectrum, fluorescence emission spectrum, viscosity measurement and gel electrophoresis, and insertion of barbaloin to DNA was identified.Higher concentration of barbaloin could convert DNA configuration of hepatoma carcinoma cell Bel  7402 from superhelix to indention. Keywords: barbaloin; molecular recognition; DNA Aloe Vera is a commonly used traditional Chinese medicine for the treatment of such burns, scald and other diseases and are widely used in food and cosmetics industries, and is. Aloe-emodin glycoside (Figure 1) is the main component of tuber Aloe, aloe-emodin glycosides different plants of the main existing forms, through non-enzymatic conversion of aloe-emodin glycosides, it is often get is aloe-emodin glycosides and iso - a mixture of aloe-emodin glycosides [1,2]. Aloe’s anti-bacterial, anti-inflammatory, anti-oxidation, etc. and the presence of aloe-emodin glycosides is closely related to [3,4]. Aloe-emodin glycosides in vivo by metabolic transformation to play for the pharmacological effects of aloe-emodin [5,6]. Figure 1 aloe-emodin glucoside and aloe-emodin glucoside different molecular structure (abbreviated) Fig.1 The molecular structure of barbaloin and isobarbaloin In recent years, studies have