Alzheimers Vaccine.docVIP

 PAGE \* MERGEFORMAT 16 Alzheimer’s Vaccine [Keywords:] Alzheimer’s vaccine Alzheimer’s disease, also known as Alzheimer (AD), is a kind of memory loss, cognitive impairment, abnormal behavior, characterized by degenerative brain disease. So far, AD pathogenesis is not entirely clear, nor very good medication. Most researchers believe that, amyloid (A deposition in the brain of AD pathogenesis exception key, so study how to block and delay the accumulation of A in early AD patients and how to eliminate the formation of A treatment of AD plaque deposits to become an entry point. immunological methods through the reduction and removal is the treatment of AD, A may be an important way to A immunogen prepared as a vaccine to intervene in the treatment of AD has become an important direction, this paper AD vaccine the latest developments. A theoretical basis for vaccine development Theoretical basis for vaccine development from the people of AD etiology and pathogenesis of understanding. Recent study found that environmental or genetic mutations lead to amyloid precursor protein (APP) metabolism, in neuronal extracellular amyloid deposits, the formation of early old the center spot, and caused neuronal damage, brain atrophy caused by dementia. On the pathogenesis of AD, A is now generally considered to be the cause doctrine. AD pathology in the nerve cells showed a large number of between the deposition of amyloid fibrils, nerve cells appeared in neurofibrillary tangles, accompanied by nerve cell death, neural synapses and cortical neurons of cholinergic receptor loss. A is the -secretase and -secretase enzymes break down APP formation. A oligomer formation can be gathered and the spread of A derived ligands, they can fast, high-affinity and of the combination with the synaptic and membrane, causing calcium influx and apoptosis (1,2). A also induced lipid peroxidation, free radicals and reactive oxygen species, free radicals and reactive oxygen sp