Amiodarone and magnesium sulfate in the treatment of refractory ventricular arrhythmias.docVIP

 PAGE \* MERGEFORMAT 6 Amiodarone and magnesium sulfate in the treatment of refractory ventricular arrhythmias [Keywords:] ventricular arrhythmias Ventricular arrhythmias Sudden cardiac death was considered an independent risk factor. Refractory ventricular arrhythmia in clinical practice common means the 2 ~ 3 kinds of anti-arrhythmic drug therapy ineffective or worse, except for electrolyte disturbance and drug-induced ventricular arrhythmias. In addition to the active treatment and incentives to dispose of the cause, the choice of antiarrhythmic drugs is very important. Amiodarone and magnesium sulfate treatment of refractory ventricular arrhythmias, efficacy and good safety are summarized below. An arrhythmia etiology and pathogenesis of 1.1 The cause of arrhythmia Arrhythmia can be found in a variety of organic heart disease, of which coronary atherosclerotic heart disease, cardiomyopathy, myocarditis, and rheumatic heart disease is more common, especially in the event of heart failure or acute myocardial infarction. Occurred in the basic health or autonomic dysfunction is not uncommon in patients with arrhythmia. There are other causes of electrolyte, or endocrine disorders, anesthesia, cold, chest or heart surgery, drug effects and central nervous system diseases, some of unknown etiology. 1.2 Mechanism of arrhythmia A large number of single-celled, free muscle strip and animal cardiac electrophysiology study showed that the incidence of arrhythmia in a variety of different mechanisms, such as return, self-discipline to change, triggering excitement (the latter causing depolarization) and the modulation of the parallel shrinkage. Electrophysiological mechanisms of arrhythmia include an exception occurs impulse, the impulse conduction abnormalities, as well as the two co-exist. Impulse exception occurs commonly found in: (a) normal state of self-discipline, the normal pacemaker points (the highest and the potential pacemaker) bit 4 divided by a ve