And regulation of P2X purinoceptor.docVIP

 PAGE \* MERGEFORMAT 11 And regulation of P2X purinoceptor [Abstract] ATP (adenosine triphosphate, ATP) is the composition of the cell material and energy, but also play a biological role in the organization of signaling molecules. ATP receptors in the purinergic receptor belonging to P2 purinoceptor classification (P2 receptor). With the gradual P2X receptor subunits clarify and 7 have been cloned, P2X receptors are found in many features, especially some of the material to its modulation of attention and research in recent years the focus of These studies may be of clinical pharmacy and mechanism of some diseases, provide new ideas. [Keywords:] ATP, pain, P2X receptors, DRG * Foundation item: National Natural Science Foundation of China P2 receptors are widely distributed in various tissues and systems in the body, according to its molecular structure and signal transduction mechanism of P2X and P2Y receptors were divided into, is now generally accepted that P2X ligand-gated cation channel, P2Y is a G - protein-coupled receptor. the first study on the P2X receptor pharmacology is only limited research into the mid-twentieth century, 7 species have been cloned P2X receptor subunits, the research it was leaps and bounds. In this paper, in recent years to P2X receptor structure, distribution and regulation are reviewed. 1 P2X receptor structure P2X 7 receptor subunits at least 50% amino acid sequence homology, amino acid number ranging from 379-595. [1] based on amino acid sequence of P2X receptor subunits, suggesting that the receptor structure includes M1 and two transmembrane domains M2, M1 and M2 of the cell connecting the outer ring, the different length of the intracellular C-terminal and N terminal [2], N end of the short (lt;30 amino acids), C terminal’s length from P2X6 residues 25 to 240 residues P2X7 range, and its intracellular phosphorylation sites in the C terminal system [3]. ATP molecules and receptor binding sites,