Antagonism of Chinese medicine Tripterygium wilfordii Anti-fertility activity of.docVIP

 PAGE \* MERGEFORMAT 18 Antagonism of Chinese medicine Tripterygium wilfordii Anti-fertility activity of Abstract TWP as a new immunosuppressive agent has been more and more widely in clinical applications, however, occur under the action of its treatment side effects can not be overlooked, especially on the reproductive system damage. Traditional Chinese medicine five sub-four stone material melon soup, Effect of DSS, Wu Zi Yan Zong Wan, yang side, Qi Huo Xue Fang, kidney and other drinking could antagonize the anti-fertility activity of TWP. Keywords: TWP reproductive system side effects of traditional Chinese medicine antagonist Tripterygium glycosides, the main ingredient is Wilforlide, triptotriterpenic acid B, triptotriterpenic acid A, is currently mainly used in the treatment of chronic nephritis, Henoch-Schonlein purpura nephritis, nephrotic syndrome, hepatitis B virus associated nephritis, diabetes, kidney disease and various immune system diseases. Now for the application of TWP in the dosage, this has been not only stay in the 1 mg / kg * d, some scholars [1] try to use double dose of 2 mg / kg * d, improved clinical efficacy. However, studies have found that triptolide autoimmune dose was significantly higher than its effective anti-fertility threshold dose [2] shows that triptolide, while playing the immune inhibition inevitably affect reproductive functions. Wu States, etc. [3] the use of flow cytometry technology TWP cytotoxicity to explore, pointing out that TWP pairs of T lymphocytes has a direct cytotoxic effect, and its toxic dose with the TWP increase increased. How to mitigate the damage TWP right gonad and increase the long-term efficacy has become a serious problem, many researchers turned to the vast Chinese medicine market, hoping through the traditional Chinese medicine preparations, and with the use TWP to achieve enhanced efficacy, side effects of antagonistic purpose. 1 TWP gonadal damage caused