Aplastic anemia medicine against apoptosis of bone marrow status.docVIP

 PAGE \* MERGEFORMAT 18 Aplastic anemia medicine against apoptosis of bone marrow status [Keywords:] aplastic anemia, apoptosis, Chinese medicine; Summary Aplastic anemia (hereinafter referred to as “AA”), the occurrence of closely related with immune system disorders, including T lymphocytes in the immune pathogenesis an important role. Bone marrow failure in the main and activated cytotoxic T cells (CTL) For, T cell subsets and activation of T cells change, resulting in the secretion of cytokines imbalance can produce a lot of negative regulation of hematopoietic cytokines, also activate the apoptosis system, causing bone marrow failure. Most of the immune suppression in AA agent treatment is effective, clinical observation and experimental studies support the immune pathogenesis of aplastic anemia. Therefore, to correct immune dysfunction, against hematopoietic stem cell apoptosis, proliferation and differentiation to protect its function, is the basic principle of treatment of aplastic anemia. consists of 11 amino acid peptide cyclosporin A ring A (CsA) is a highly specific immunosuppressant, is an effective drug in the treatment of aplastic anemia [1-3], but efficiency is about 50%. In view of some of the clinical treatment of aplastic anemia in patients with CsA is invalid, there is an urgent need to find other drugs in the treatment of aplastic anemia [4]. At present, Chinese medicine treatment of aplastic anemia patients in the fight against bone marrow cells of aplastic anemia have made encouraging progress, are summarized below. 1 cells of aplastic anemia associated with brief Cells (apoptosis), also known as programmed cell death (programmed cell death, PCD), is to maintain homeostasis, the genes controlling self-ordering of cell death [5]. The occurrence of apoptosis genes expression, protein synthesis and intracellular Ca2 + concentration increased and many independent biological behavior of different signal transduction system mediate