ApoE gene polymorphism and serum lipid levels of correlation.docVIP

 PAGE \* MERGEFORMAT 2 ApoE gene polymorphism and serum lipid levels of correlation Author: Liu Yingli, Li Branch, Yan self-improvement, Chen Yanjiong [Keywords:] gene Correlation between apolipoprotein E gene polymorphism and plasma lipid level [Abstract] AIM: To evaluate the effects of apolipoprotein E (ApoE) gene polymorphism on the plasma lipid level. METHODS: Seventytwo hypertensive patients (male 46, female 26) and 95 healthy controls (male 46, female 49) were examined for their plasma lipid level (TC, TG, HDLC and LDLC) and ApoE gene type. RESULTS: The allele frequency distribution was similar between the 2 groups and ε 3 allele frequency distribution was the highest, which was 80.5% in normal group and 76.8% in hyperlipemia group. ε 2 and ε 4 allele frequency distributions were lower than ε 3. There was no significant difference between different sexes. ApoE gene type was correlated with serum lipid levels. Serum lipid be normal or not, TC and LDLC level was ε 2/3ε 3/3ε 3 / 4 and HDLC was ε 3/4ε 3/3ε 2/3. CONCLUSION: ApoE gene polymorphism is significantly correlated with serum lipid level. [Keywords] apolipoprotein E; gene polymorphism; hyperlipemia [Abstract] Objective: To analyze the ApoE gene polymorphism and lipid abnormalities. Methods: 72 patients with high blood lipids (male 46, female 26) cases, 95 normal controls (male 46, female 49) cases to fasting TC, TG, HDLC, LDLC detection and ApoE genotyping. Results: ApoE allele frequencies in the distribution of two populations have the same trend, the highest frequency allele ε 3, blood lipids and normal group was 80.5%, dyslipidemia was 76.8%, which is our country crowd of the most common allele, ε 2 and ε 4 was relatively small. male and female allele frequencies between the sexes was no significant difference. ApoE genotype and serum lipid levels are related, whether abnormal or normal blood lipids, serum TC among different genotypes , LDLC from low to high order of ε 2 / 3