Apoptosis after peripheral nerve injury and the protective effect of traditional Chinese medicine Experimental Research.docVIP

 PAGE \* MERGEFORMAT 40 Apoptosis after peripheral nerve injury and the protective effect of traditional Chinese medicine Experimental Research Authors: Xiao-Feng Li, Xu Yue-Qin, Xi Zhi-Jie, Zhou reconstruction [Keywords:] peripheral nerve injury; apoptosis; Review Progress of experimental study on cell apoptosis after peripheral nerve injury and the protective effect of Chinese medicine With modern molecular biology, tissue engineering, cell biology, genomics, maturity and popularity, and computer software development and application of peripheral nerve injury made substantial progress in basic research, now widely recognized that peripheral nerve injury caused by nerve cell death mainly in the form of apoptosis [1]. In this paper, after peripheral nerve injury in recent years for the apoptosis and the protection of a comprehensive overview of experimental research. A peripheral nerve injury mechanism of apoptosis after Peripheral nerve injury induced apoptosis of multiple physiological and pathological factors involved in apoptosis-related genes activated by programmed cell death process, in this process in addition to apoptosis-related proteins, and many inflammatory mediators, cytokines, calcium ion and Deng Jun of reactive oxygen species affect apoptosis. Are described below. 1.1-induced apoptosis and cytokine genes 1.1.1 The low-affinity nerve growth factor receptors in recent years, research results show that nerve growth factor low affinity receptor p75NTR intracellular membrane area contained in the chopper near the domain structure and function s  p75NTR (short p75NTR) independently induced cell apoptosis [2,3]. Barker et al [4] experiments further proof of this point of view, in the expression of encoding only the soluble p75NTR intracellular domain peptide gene in transgenic mice, the sympathetic neurons and sensory neurons in the death of a significant increase. Also reported in the adult peripheral nervous system did not express p75NTR