Apoptosis and pancreatitis.docVIP

 PAGE \* MERGEFORMAT 12 Apoptosis and pancreatitis Keywords:: apoptosis pancreatitis The pathogenesis of pancreatitis, but from the nature of apoptosis and pancreatitis to clarify the relationship between the molecular mechanisms of apoptosis should be to conduct a study. Now that the apoptosis involved in pancreatitis There are two main mechanisms: one is subject to genetic regulation; and those of non-gene regulation. 1 gene regulation By the gene regulation of cell apoptosis, also known as programmed cell death. Generally fall into two categories: one category is a direct control, such as cancer genes; the other which is an indirect regulation. Such as bio-active molecules, by inducing the expression of oncogenes play a regulatory role. Cancer gene bc1-2 gene family is the most concerned with one of the apoptosis-related genes. Wada et al [1] on the pancreatic duct ligation (PDL) mice using anti-bc1-2 monoclonal antibody and anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody with Western blot and immunohistochemical method bc1-2 and PCNA were detected. The results showed that, PDL rat pancreatic ductal epithelial cells of the bc1-2 expression in the fourth, five days 2 to 5 times higher than that. bc1-2 and PCNA immunostaining in the control group of pancreatic ductal epithelium to the weak staining in the PDL rat pancreatic ductal leather bcl-2 and PCNA immunostaining positive cells increased, respectively, in the second and third day, reached the highest value. The results show that, bc1-2 can inhibit apoptosis of pancreatic ductal epithelial cell function. To further study the bc1-2 gene family in the role of various genes, Miyamoto et al [2] research PDL and caerulein-induced experimental model of acute pancreatitis in two kinds of mouse and human chronic obstructive pancreatitis (COP) of pancreatic exocrine cells in bc1-2 family related gene expression. The results showed that in normal pancreas was no expression of bc1-2 gene famil