Apoptosis in the nervous system.docVIP

 PAGE \* MERGEFORMAT 15 Apoptosis in the nervous system Keywords:: nervous system pro-apoptotic genes of apoptosis anti-apoptosis genes People on the nervous system apoptosis, especially apoptosis and the relationship between the understanding of nervous system diseases later 〔 1〕 . In recent years, found that apoptosis not only occurs in embryogenesis and normal development of the process, but also appeared in pathological situations. In the nervous system, cancer, epilepsy, ischemia, trauma, and Alzheimer disease, Parkinson’s disease, amyotrophic lateral sclerosis and other neurological degeneration, apoptosis, upon their participation, to explore its molecular and genetic mechanisms, can people from a new perspective in their understanding nervous system diseases, the mechanism and control strategies. In this paper, a general overview of apoptosis in the nervous system in recent years after the research progress of apoptosis are reviewed. Apoptosis in a concept, identification of targets and gene regulation 1.1 The concept of apoptotic cell death in two ways, namely, apoptosis and necrosis. Apoptosis is an energy-dependent active process of cellular self-destruction. Features of apoptosis and mitosis the contrary, the selective removal unwanted cells to ensure the stability of the number of tissue cells. 1.2 Identification of indicators of apoptosis ① morphological criteria, that is, a typical three-stage apoptosis; ② biochemical indicators, namely, DNA chains are specific DNA endonuclease cut between the nucleosomes to form with 180 to 200 base pairs, or its multiple base-pair DNA fragments; ③ pharmacological targets to curb some of the translation and transcription-related molecules can block apoptosis, indicating that cells need to generate a number of new protein and RNA apoptosis can be achieved. 1.3 apoptotic gene regulation ① ced-3/ICE family; ② bcl-2 family; ③ P53. In different types of cells, also found that several other pro-apoptotic