Apoptosis-related gene in adenoid cystic carcinoma of the expression and significance.docVIP

 PAGE \* MERGEFORMAT 6 Apoptosis-related gene in adenoid cystic carcinoma of the expression and significance [Abstract] Objective: To analyze the apoptosis-related genes p 53 and bcl-2 in orbital adenoid cystic carcinoma of the expression analysis of their relationship and clinical significance. Methods: Immunohistochemistry was used to detect 51 cases of adenoid cystic carcinoma clinical specimens and 10 cases of normal orbital tissue P53 and Bcl-2 protein expression status. Results: P53 and Bcl-2 in orbital adenoid cystic carcinoma tissues positive rates were 53% and 65%, significantly higher than the orbital normal tissues (53%, 65% vs 10%, P amp;lt;0.01). Solid-type adenoid cystic carcinoma in the expression of P53 was significantly higher than in adenoid - tubular type of the expression rate (86% vs 30%, P amp;lt;0.01); P53 and Bcl-2 expression in the recurrence group rate was significantly higher than that in the early onset group in the expression rate (85% vs 42%, P amp;lt;0.01), (100% vs 53%, P amp;lt;0.01); P53 and Bcl-2 expression as the two relevant (χ 2 = 1.461, Pamp;gt; 0.05). Conclusions: P53 and Bcl-2 protein detection for determining tumor sensitivity to chemotherapy and prognosis of reference value. [Keywords:] orbital adenoid cystic carcinoma of the resistance of apoptosis-related genes 0 Introduction Adenoid cystic carcinoma (adenoid cystic carcinoma, ACC) is a highly malignant epithelial tumors, can occur in various parts of the body, such as the salivary gland, submandibular gland, trachea, lung, breast, skin, and so on, in the eyes then occur in the lacrimal gland [1]. We pass the test of orbital adenoid cystic carcinoma of the expression of apoptosis-related genes, understanding and analysis of apoptosis-related genes p 53 and bcl-2 in orbital adenoid cystic carcinoma of the expression and histologic types and prognosis and clinical significance. We used gene detection method is the protein level by immunohistochemistry, which is th