Apoptosis and necrosis of femoral head bone related research.docVIP

 PAGE \* MERGEFORMAT 13 Apoptosis and necrosis of femoral head bone related research Of: Bing-Li, Sun Wei, Cheng Liming, LEE Chi [Keywords:] femoral head necrosis Also known as ischemic necrosis of femoral head osteonecrosis or aseptic necrosis of femoral head, occurs mainly in the young people, mostly in the age of onset between the ages of 30 and 59. [1] to the later development of the disease can lead to femoral head collapse and secondary degenerative arthritis, seriously affected the normal life of the patient, is a very high morbidity of the disease. it is regrettable that the exact pathogenesis of this disease remains unclear, and bone necrosis of the known factors related to more than 150 species. traumatic femoral head necrosis due to direct damage to the bone’s blood supply, leading to bone cell ischemia, hypoxia until the bone cell death or apoptosis. non-traumatic osteonecrosis of the exact cause yet, the current on non-traumatic femoral head necrosis in the pathogenesis of a variety of theories, including: a) osteoporosis theory, b) theory of bone cell damage, c) theory of lipid metabolism disorder, d) high-pressure theory of bone, e) intravascular coagulation theory and so on. In recent years, some scholars of bone cell apoptosis is the main reason for femoral head necrosis, and a lot of work in this regard, this paper makes a summary in this regard. 1 Apoptosis of bone necrosis Apoptosis, also known as programmed cell death, that is, cells in certain physiological or pathological conditions, following the end of the process the process of life itself, shedding the last cell in vitro or cracking for a number of apoptotic bodies engulfed by other cells. The process includes the following phases: the excitation of apoptosis, intracellular signal transduction and regulation of apoptosis, activation of apoptosis effectors, protein and DNA molecules break, cell death. currently there are many scholars believe that the hormone induced bon