Apoptosis Mechanisms of signal transduction.docVIP

 PAGE \* MERGEFORMAT 21 Apoptosis Mechanisms of signal transduction [Keywords:] Apoptosis, death receptor, mitochondria, endoplasmic reticulum, granzyme B, Anoikis, caspase family of poly-linking reaction Apoptosis is acceptable under certain conditions, cell stimulation signals and gene regulation by an autonomous, programmed cell death process. Can occur in physiological and pathological conditions. On the mechanism of apoptosis in mammalian cells are Following several pathways: death receptor mediated apoptosis pathway, mediated mitochondrial apoptosis pathway, endoplasmic reticulum-mediated apoptosis pathway, granzyme-mediated apoptosis pathway, Anoiki mediated apoptosis pathway. In addition, several of these pathways common way late caspase family activation. 1 receptor-mediated apoptosis via apoptosis Death receptor pathway of apoptosis, also known as apoptosis in the external way. Death receptor ligands combined with the corresponding be activated, after the downstream signaling cascade series, step by step starting caspase activation (eg, caspase 8 (1) and the effect of caspase (caspase 3,7, etc. (2), ultimately leading to cell apoptosis. according to the signal transduction pathway can be divided into the following three categories. Represented 1.1 Fas receptor-mediated signal transduction The approach represented by the death receptor Fas-mediated start, the death inducing signal complex (death inducing signal complex, DISC formation is a key step in the cascade reaction (3). Fas and Fas receptor binding receptors poly of, cytoplasmic death domain (death domain, DD) also occurred in oligomerization, the Fas activation. activated Fas recruits Fas associated death domain protein (fas associated death domain protein, FADD.FADD hand side of the DD through the C with Fas, on the other hand, through its N-induced apoptosis with the ability of the death effector domain (death effector domain, DED recruitment of procaspase 8, FADD pro