Apoptosis in osteoarthritis research.docVIP

 PAGE \* MERGEFORMAT 13 Apoptosis in osteoarthritis research [Abstract] chondrocyte apoptosis in osteoarthritis (OA) plays an important role in the pathogenesis, there is NO way of apoptosis pathways and Fas channels; mainly affected by Bcl  2 gene family, Bax, P53, ICE, and c  myc gene family regulation; cartilage extracellular matrix degradation can induce chondrocyte apoptosis. Clarify the chondrocyte apoptosis in the pathogenesis of OA in the role will contribute to prevention and treatment of OA. [Keywords:] osteoarthritis; cartilage cells; apoptosis; Review Abstract: Cartilage apoptosis functions a lot in OA occurrence.Its apoptosis has two ways of NO and Fas, mainly controlled by Bcl  2 gene family, Bax, P53, ICE and c  myc gene family; the degeneration of cartilage cell base can induce apoptosis.It shows cartilage apoptosis function in OA occurrence, helpful to prevention and treatment of OA. Keywords:: OA; cartilage cell; apoptosis; review Osteoarthritis (osteoarthritis, OA) is a kind of degeneration of articular cartilage and secondary osteoarthritis as the main pathological features of chronic bone and joint disease in clinical practice in order to slow nature of joint pain, stiffness, swelling with joint dysfunction as the main performance. Cell apoptosis (apoptosis) is a genetically controlled by and dependent on ATP supply to the cell autonomy of death. With the development of cellular and molecular biology, many scholars at home and abroad found that chondrocyte apoptosis in OA of the occurrence and development plays a key role [1  2]. In this paper, osteoarthritis articular cartilage in recent years, the study of apoptosis are summarized below. 1 Distribution of chondrocyte apoptosis and proportion of Apoptosis or programmed cell death, in 1972, was first described in Kerr, generally considered the procedure leading to apoptosis in the body, was activated under the action of external factors, leading to cell apoptosis. Studi