Apoptosis and Cancer Therapy.docVIP

 PAGE \* MERGEFORMAT 15 Apoptosis and Cancer Therapy Keywords:: apoptosis of cancer anti-cancer drug Abstract vivo by a variety of tissue cells proliferation and apoptosis to maintain the number of balance. Once this balance is broken and will lead to the emergence of some diseases such as cancer. Apoptosis and cancer, the relationship between the treatment of cancer provides a new idea. Anti-cancer drug research has gone through a long process of development, despite the cells of many anticancer drugs target a certain understanding, but for How the drug and tumor cell death leading to the exact mechanism is unclear. In recent years, studies have found cells in a variety of anti-cancer drug-induced apoptosis is the main form of cell death, allowing apoptosis and the relationship between cancer and cell apoptosis in cancer treatment The role of a new focus of anti-cancer research. 1 cell apoptosis Of cell death in general there are two ways, namely, necrosis (necrosis) and apoptosis (apoptosis). Cell necrosis usually occurs in contact with a group of cells is determined by various non-physiological factors, such as ischemia and other difficult to control due to a destructive phenomenon. It does this by interfering with cellular energy metabolism, causes cells to osmotic imbalance, swelling of the cytoplasm, and ultimately by lysosomal enzymes leading to irreversible destruction of cell structure and to induce local inflammatory response. The concept of apoptosis was in 1972 by Kerr and Wyllie, etc. concerned. It is an active, inherently programmed phenomenon, it is also known as programmed cell death (programmed cell death, PCD). Many physiological, non-physiological factors that can cause apoptosis, such as radiation, heat, toxins and various anti-cancer drugs. The necrosis is essentially due to cell-week Wai environment of serious injury-induced changes, so these two processes in the event of mechanisms, morphology and biochemistry aspects were differen