Application of oral cholera vaccines.docVIP

 PAGE \* MERGEFORMAT 8 Application of oral cholera vaccines [Abstract] Objective of the international and domestic application of oral cholera vaccines overview of the progress to achieve better used in a clinical practice. Methods of inactivated whole bacterial cholera vaccine (WC vaccine), inactivated whole bacteria plus B subunit cholera vaccine (WC / rBS vaccine) and live attenuated cholera vaccine (CVDl03-HgR live attenuated vaccine) the practical application of to conduct a comprehensive analysis of induction. Results rBS-WC are convinced that the protective effect, while CVD103-HgR live oral attenuated vaccine is an urgent need for prompt access to protector. Conclusion Because of live cholera vaccines that may occur related to the level of virulence genes gene transfer, with a high incidence of potential side effects. Should be based on different circumstances, consider selecting a different oral vaccines. [Keywords:] oral cholera vaccine; WC vaccine; WC / rBS vaccine; CVDl03-HgR live attenuated vaccine Cholera is caused by Vibrio cholerae potent intestinal infectious diseases, clinical painless diarrhea to severe vomiting, Mi Ganshui-like stools, severe dehydration, muscle cramps and peripheral circulatory failure, etc. characterized. After the founding of New China, our country has been eliminated from the disease, the recent domestic outbreak from time to time in some areas and must therefore be vigilant, to take preventive measures seriously. The 20th century, 60 years, the international community has developed a variety of parenteral cholera vaccine, but because of adverse events re-protect the power of only 50% within a short period of protection, WHO Expert Committee on Biological Standardization decided to stop using since 1999. Oral vaccine can induce intestinal produce antibodies, while the gut is the front line of the fight against cholera. Moreover, the oral vaccine can also reduce medical costs and avoid unnecessary medical harm, theref