Asarum and verapamil Experimental Study of Analgesic synergy.docVIP

 PAGE \* MERGEFORMAT 9 Asarum and verapamil Experimental Study of Analgesic synergy 【Abstract】 Objective To study the analgesic Asarum and verapamil synergies, in order to provide a theoretical basis for clinical combination therapy. Methods The mouse acetic acid writhing test and hot-plate-induced pain and analgesic effect of experimental observation of experimental drugs, and use neural boxes, multimedia, MS-302 system, observe the effect of toad sciatic nerve action potential impact. Results Asarum and AV compound on acetic acid induced abdominal pain, hot plate-induced pain in mice have shown adequate analgesic effect and can inhibit the conduction of action potentials of toad sciatic nerve. Verapamil a weak analgesic effect, no effect of sciatic nerve action potential block. AV compound preparation of the analgesic and inhibit nerve action potential conduction is greater than both component Asarum and verapamil. Conclusion Asarum and verapamil have analgesic synergy. Keywords: Asarum; verapamil; analgesic effect Research of Analgesia Synergism of Asarum and Verapami Abstract: ObjectiveTo research synergetic analgesic effect of Asarum and Verapamil, in order to apply theoretical evidence for clinical administration.MethodsAdopt acetic acid turning body experiment and hot board method inducing pain experiment to observe their synergetic effect, and the influence of action potential of toad sciatic nerve by nerve chamber, multi-media MS-302 system.ResultsAsarum and AV compound have remarkable analgesic effect of the pain of mice induced by acetic acid turning body and the hot-plate test. Both can inhibit action potential transmission of toad sciatic nerve. Verpamil has faint analgesic effect but can not inhibit action potential transmission of toad sciatic nerve. AV compound has greater effect of analgesia and inhabiting nerve action potential transmission than its components Asarum and Verapamil.Conclusion Asarum and Verapamil have a