Asarone solubility and hydroxypropyl cyclodextrin Investigation.docVIP

 PAGE \* MERGEFORMAT 7 Asarone solubility and hydroxypropyl cyclodextrin Investigation Of: Wang Guangming, Wang Zhenhua, Pan Yan, Kongqiu Ling, Tian Jun [Abstract] Objective To study the solvent, temperature and solubility of cyclodextrin on asarone. Methods Using HPLC-UV method to determine asarone in different solvents, different temperatures and under different concentrations of cyclodextrin solution solubility. The results detailed Xin cerebral small solubility in water, in the tea oil, ethanol, methanol, higher solubility, cyclodextrin can increase the amount dissolved in water. Conclusion asarone is water insoluble components, the use of high concentrations of cyclodextrin can increase its solubility in water. [Keywords:] asarone, solubility, CD Asarone is gramineus Araceae Acorus tatarincuii Schott perennial herb extracts, the study found @ - asarone has a good cough, phlegm, asthma, sedative, antispasmodic and anticonvulsant role in the clinical on the applied pneumonia, asthma and seizures, there were more satisfactory results [1]. asarone, also known as @ - asarone asarone and asarone (Asarone), chemical name is 2,4,5 - trimethoxy -1-- propylene benzene, soluble in ethanol, ethyl acetate, ether and chloroform, insoluble in water [2]. For ease of preparation of this article asarone measured in different solvents and hundreds of different quality sub-cyclodextrin concentration of hydroxyl solubility in solution. An instrument and reagent Dionex HPLC (P680 HPLC UVD170U detector), Agilent HC-C18 column (5 m, 250 mm 4.6 mm, Sartorius BP110S analytical balance, KQ5200DE CNC ultrasonic cleaner (Ultrasonic Instrument Co., Ltd., Kunming, SHZ-88 Desktop constant temperature bath oscillator (calibrated using a mercury thermometer prior to reading). @ - asarone standard (10298-0001, Drug and Biological Products in China to provide, @ - asarone materials (Hubei Hope Pharmaceutical Co., Ltd.), -cyclodextrin (lot number: National Pharmac