Astragalus Polysaccharide on focal cerebral ischemia-reperfusion injury in rats.docVIP

 PAGE \* MERGEFORMAT 14 Astragalus Polysaccharide on focal cerebral ischemia-reperfusion injury in rats Author: Kui Yu Si-ming, Liu Ping, Zhou Yi pairs of heaven and earth [Abstract] Objective: To study the astragalus polysaccharide on rat focal cerebral ischemia-reperfusion injury protection. Methods: Using the intraluminal suture method of middle cerebral artery occlusion (MCAO) produced in rats with focal cerebral ischemia-reperfusion injury model, and rats were randomly divided into sham operation group, model group, astragalus polysaccharide low, medium and high-dose group, at reperfusion after 1 day, 3 days, the first 7 days were sacrificed and sampled in each group of rat brain tissue water content, superoxide dismutase (SOD), malondialdehyde (MDA) changes, supplemented with Triphenyl tetrazolium chloride (TTC) staining of infarct changes. Results: Compared with sham-operated group, model group, brain tissue water content and MDA content was significantly increased infarct volume significantly increased, SOD was significantly reduced; Compared with model group, astragalus polysaccharide with various doses of brain water content, MDA content in significantly decreased, SOD was significantly increased infarct size is also significantly reduced. Conclusion: Astragalus polysaccharides can reduce the brain water content, MDA levels, SOD increased the level of ischemic brain damage have a certain protective effect. [Keywords:] astragalus polysaccharide cerebral ischemia-reperfusion injury in brain water content SOD MDA Protective Effect of Astragalus polysaccharide on Focal Cerebral Ischemia-Reperfusion Injury in Rats [Abstract] Objective: To study the protective effect of Astragalus polysaccharide on focal cerebral ischemia-reperfusion in jury in rats.Methods: The models of focal brain ischemia-reperfusion injury was prepared by middle cerebral artery occlusion (MCAO) in SD-rats. The rats were randomly divided into sham operation control group, model