Atorvastatin in patients with acute spontaneous intracerebral hemorrhage in serum IL1 TNF and the level of MMP2.docVIP

 PAGE \* MERGEFORMAT 9 Atorvastatin in patients with acute spontaneous intracerebral hemorrhage in serum IL1 TNF and the level of MMP2 [Abstract] Objective To atorvastatin in patients with acute intracerebral hemorrhage IL 1, TNF @, MMP 2 explore the effect of atorvastatin in patients with acute cerebral hemorrhage cerebral protection. Methods 60 hospitalized patients with spontaneous intracerebral hemorrhage were divided into 4 groups: acute cerebral hemorrhage with normal lipid group (A group, n = 10, high blood cholesterol in acute intracerebral hemorrhage group (AH group, n = 20, acute cerebral hemorrhage with normal lipid atorvastatin treatment group (AT group, n = 12, high blood cholesterol in acute intracerebral hemorrhage atorvastatin treatment group (AHT group, n = 18.ELISA Determination of IL 1, TNF @ and MMP 2, Determination of lipid biochemistry. Results AT serum levels of IL 1, TNF @ , MMP 2 concentration and A group was significantly lower (P lt;0.05, after atorvastatin treatment after 2,4,6 w IL 1, TNF @, MMP 2 and the concentration value before treatment showed no significant change (Pgt; 0.05 ). AHT serum levels of IL 1, TNF @, MMP 2 concentration and AH group was significantly lower (P lt;0.01, after atorvastatin treatment after 4,6 w IL 1, TNF @, MMP 2 concentration and treatment 2 w values decreased significantly compared (P lt;0.01. Conclusion Atorvastatin in patients with acute intracerebral hemorrhage can lower serum IL 1, TNF @, MMP 2 levels, and can inhibit the inflammatory response and maintain the integrity of blood-brain barrier function play a role in cerebral protection . [Keywords:] acute spontaneous intracerebral hemorrhage, atorvastatin, inflammation, blood-brain barrier Statins, the 3-hydroxy 3-methyl glutaric acid mono-coenzyme A (HMG CoA) reductase inhibitors, are a class of powerful cholesterol-lowering drugs, with a safe, well tolerated, etc., these drugs In addition to significantly outside the regulation of blood