Astemizole of the rare adverse reactions.docVIP

 PAGE \* MERGEFORMAT 6 Astemizole of the rare adverse reactions Astemizole (astemizole) is a role of the strong, long-acting H1 receptor antagonist, there is no central sedative and anticholinergic effects. Is widely used in urticaria, allergic rhinitis, allergic conjunctivitis and other diseases treatment effect is significant. However, in use, recently found some rare adverse reactions, are summarized below. An exfoliative dermatitis Xiang Wei-jun [1] reported 1 cases of allergic rhinitis patients, I Astemizole 10mg / d, 3d skin start to appear after the body flushing, swelling, with burning sensation. Increase the dose to 20mg / d, disease continued to increase, not opened his eyes, conjunctival hyperemia, erosion and neck, trunk, limbs, a large number of scaling. Disable Astemizole, after intravenous dexamethasone, add a large number of vitamin C, and symptomatic treatment recovery. Also in January after the patient self-service Astemizole, once again the above-mentioned symptoms, cured by timely treatment. 2 Epilepsy One cases of patients with generalized pruritus and rash, self-service Astemizole 10mg, interval occurs around 2h spastic limbs, convulsions, restlessness, transient loss of consciousness, accompanied by dizziness, chest tightness embolism. Immediate intramuscular injection stability 10mg, intravenous infusion of energy mixture, 2 ~ 3h after the onset of paroxysmal there, but also oral phenytoin 0.1g, three times a day, three days after the relief of symptoms [2]. 3 Pronunciation unclear 1 cases of allergy sufferers I Astemizole 3mg, once a day, after the 2nd medication patients pronunciation is unclear, given oryzanol 5mg, three times a day, Vitamin B1 10mg, three times a day, and even served 5 days, the symptoms gradually disappears [3]. 4 anaphylactic shock Female patient, 28 years old. Because of urticaria 2h I Astemizole 10mg, drug 10min later, the patient fell to the ground fainting, pale, limb weakness, difficul